Jia Huang Laboratory

Mitigating xenogeneic barriers to chimerism through Cas13-induced host attenuation

He, B., Lv, S., Li, L., Zhang, L., Hu, Y., Okamura, D., Huang, J.*, & Wu, J.*

Developmental Cell

Recent advances in interspecies chimeras and organogenesis

Huang, J., He, B., & Wu, J.

Current Opinion in Genetics & Development, 93, 102368

Generation of rat forebrain tissues in mice

Huang, J., He, B., Yang, X., Long, X., Wei, Y., Li, L., Tang, M., Gao, Y., Fang, Y., Ying, W., Wang, Z., Li, C., Zhou, Y., Li, S., Shi, L., Choi, S., Zhou, H., Guo, F., Yang, H., & Wu, J.

Cell, 187(9), 2129–2142.e17

Featured in: Nature (2024) "Rat neurons repair mouse brains — and restore sense of smell" · Labanimal (2024) "Crossing species boundaries in regenerative neuroscience with rat–mouse brain chimeras"

Humanizing pig kidneys via chimeric complementation

Huang, J., & Wu, J.

Cell Research, 34(3), 189–190

Chimeric Monkey Born Alive with a High Contribution of Donor Cells

Huang, J., & Wu, J.

Neuroscience Bulletin, 40(6), 849–851

Incompatibility in cell adhesion constitutes a barrier to interspecies chimerism

Ballard, E., Sakurai, M., Yu, L., Liu, L., Oura, S., Huang, J., & Wu, J.

Cell Stem Cell, 31(10), 1419–1426.e7

High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects

Tong, H., Huang, J.*, Xiao, Q., He, B., Dong, X., Liu, Y., Yang, X., Han, D., Wang, Z., Wang, X., Ying, W., Zhang, R., Wei, Y., Xu, C., Zhou, Y., Li, Y., Cai, M., Wang, Q., Xue, M., Li, G., … Yang, H.*

Nature Biotechnology, 41(1), 108–119

Endogenous promoter-driven sgRNA for monitoring the expression of low-abundance transcripts and lncRNAs

Gao, N., Hu, J., He, B., Ji, Z., Hu, X., Huang, J., Wei, Y., Peng, J., Wei, Y., Zhou, Y., Shen, X., Li, H., Feng, X., Xiao, Q., Shi, L., Sun, Y., Zhou, C., Zhou, H., & Yang, H.

Nature Cell Biology, 23(1), 99–108

Modulation of metabolic functions through Cas13d-mediated gene knockdown in liver

He, B., Peng, W., Huang, J., Zhang, H., Zhou, Y., Yang, X., Liu, J., Li, Z., Xu, C., Xue, M., Yang, H., & Huang, P.

Protein & Cell, 11(7), 518–524

Protective effect of arctigenin on ethanol-induced neurotoxicity in PC12 cells

Huang, J., Xiao, L., Wei, J. X., Shu, Y. H., Fang, S. Q., Wang, Y. T., & Lu, X. M.

Molecular Medicine Reports, 15(4), 2235–2240